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| Article Name : | | | EFFECT OF ELLAGIC ACID ON CIRCULATORY ANTIOXIDANTS AND LIPIDS DURING IRON-INDUCED TOXICITY IN EXPERIMENTAL RATS | | Author Name : | | | S.Palani, D.Santhakumari, S.Balachandar and S.Ambika | | Publisher : | | | Ashok Yakkaldevi | | Article Series No. : | | | GRT-6192 | | Article URL : | |  | Author Profile View PDF In browser | | Abstract : | | | Ellagic acid (EA) is a naturally occurring polyphenolic compound that exhibits antioxidative, anti-inflammatory, anti-hyperlipidaemic and anticarcinogenic activities in a wide range of assays both in vitro and in vivo. It occurs in various foods such as strawberries, grapes, walnuts, etc. The aim of this study was to assess the effect of ellagic acid on Iron-induced changes in the circulatory antioxidative status, micronutrients and lipid levels in a dose-dependent fashion. Male albino Wistar rats weighing 180–210 g were used to assess the effects of EA against Iron-induced damage. Three different concentrations of EA (15, 30 and 60 mg/kg body weight) were tested against Iron via intraperitonial administration. At the end of the experimental duration of 10 days, we evaluated endogenous antioxidants: both enzymatic (superoxide dismutase, catalase and glutathione peroxidase) and non- enzymatic (vitamin C and E, and reduced glutathione) status, micronutrients, lipids: cholesterol, triglycerides, free fatty acids and phospholipids in the circulation. EA significantly inhibits Iron-induced toxicity by restoring antioxidant status, modulating micronutrients and attenuating the lipid levels in the circulation. The greatest inhibitory effect was observed with 60 mg/kg body weight of EA in all the biochemical assessments and could be developed as a potential for Iron in the near future. | | Keywords : | | |
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