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| Article Name : | | | EFFECACY OF Strychnos colubrina L. EXTRACT ON BLOOD GLUCOSE, PLASMA INSULIN AND TISSUE GLYCOPROTEINS IN STREPTOZOTOCIN INDUCED DIABETIC RATS | | Author Name : | | | Sudhira A. , Kamakshamma J. , Venkateswara Rao S. | | Publisher : | | | Ashok Yakkaldevi | | Article Series No. : | | | GRT-3284 | | Article URL : | |  | Author Profile View PDF In browser | | Abstract : | | | The present study evaluated the anti-hyperglycemic activity of the Ethyl acetate extract of Strychnos colubrina L bark on blood glucose, Plasma insulin and glycoprotein contents of albino rats. SCEt was administered at doses of 150, 300 and 450 mg/kg body weight respectively on streptozotocin induced diabetic rats for 3 weeks. The aim of this study was to investigate the effect of Ethyl acetate extract of strychnos coulubrina.L (SCEt) in streptozotocin induced diabetic, which was induced in male albino Wistar rats by a single intraperitoneal injection of streptozotocin (55 mg/kg). After injection, the animals were divided into five groups viz., control group, SCEt (300mg/kg) treated group, diabetic group, diabetic + SCEt (450mg/kg) body weight for 15 days. The study shows a significant increase in the levels of blood glucose, and plasma glycoproteins, while plasma insulin levels were significantly decreased in diabetic rats. There was also a significant decrease in the level of sialic acid and elevated levels of hexose, hexosamine in the liver and kidney of diabetic rats. The diabetic animals also showed a reduction of body weights. Oral administration of SCEt reverted these changes. Thus the study indicates that strychnos coulubrina L. possesses a significant beneficial effect on glycoprotein's in addition to its antidiabetic action. | | Keywords : | | |
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